Hattr Amyloidosis was previously considered a starch. This was proved by the discovery of Rudolf Virchow. Which later proved to be wrong. In amyloidosis means starch. But it’s not really starch, it turned out later. It is a protein and is called a fibrillar protein. Which contains up to 90%. The arrangement is abnormal. How to fold it is Misfolded. When it was thoroughly studied, it was discovered that this is the beta-pleated sheet structure. There are two ways to find out, one is X-ray crystallography and the other is infrared spectroscopy.

Hereditary and Inflammatory Disorders. It is found in fiber protein. And accumulates in the tissues. What happens is that it disrupts the tissue. It causes some changes in the human body. Our body is generating many proteins at a time. It also contains a small amount of abnormal protein. Amyloidosis is a serious condition that usually affects the heart, kidneys, liver, or other organs.



HATTR amyloidosis is caused by a mutation or change in the TTR gene. Any child of these changing parents will have a 50% chance of inheriting the mutation. However, this does not necessarily mean that the child’s condition will improve. Understand your family health history and talk to your doctor who can tell you exactly how HATTR amyloidosis works in this family.


What are the most important things I want to know about ONPATTRO (patisiran)? Are there

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drop in a vein (called “intravenous infusion“). Reactions to this infusion may occur during treatment with ONPATTRO. First

You will be given medicines for each infusion to help reduce the chances of an infusion-related reaction.

Tell your doctor or nurse immediately if you notice any signs of an infusion reaction during treatment:

Brightening of the face or body, warm skin

Body aches or pains, including back, neck or joint pain

Feeling sick (nausea)

Stomach pain

Shortness of breath, cough, or difficulty breathing


Chest pain or chest pain


It’s getting cold


Feeling tired (fatigue)

Heart rate

Swelling of the face

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.


SYSTEMIC: They affect more than one organ. Simply put, it involves the involvement of more than one organ

LOCALIZED: Only one organ is involved locally.

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